The membrane of the DN66TC / NY6TC cartridge is made of hydrophilic nylon 66, which is mainly used for bio-burden reduction and sterile filtration of the final material. The nylon cartridge can filter ammonia, methyl ethyl ketone, cyclohexanone and other solvents with good chemical stability.
Features
- Not charged
- Naturally hydrophilic
- Low adsorption
Applications
- Pharmaceutical sterile filtration
- Solvent filtration
- Alkaline filtration
Quality
- 100% Integrity testing in manufacturing
- Each filter is fully traceable with unique serial number
- Manufactured in a facility which adheres to ISO 9001:2015 Practices
Flow Rate Characteristics
Specifications
Materials of Construction
| Membrane | Nylon 66 |
| Support | Polypropylene (PP), polyester (PET) |
| Core/Cage/End Caps | Polypropylene (PP) |
| End Cap Inserts | Polybutylene terephthalate (PBT) |
| Seal Material | Silicone / EPDM / Viton FEP/ PFA encapsulated O-rings |
Operating Conditions
| Max. Operating Temperature | 80°C |
| Max.Operating Pressure | 0.69 MPa@25°C 0.40 MPa@60°C 0.24 MPa@80°C |
| Max. Differential Pressure (Forward) | 0.69 MPa@25°C 0.40 MPa@60°C 0.24 MPa@80°C |
| Max. Differential Pressure (Reverse) | 0.30 MPa@25°C 0.10 MPa@80°C |
Filtration Area
| Outer Diameter | Membrane Pore Size | Area/10″ | |
| DN66TC | 71 mm | 0.22+0.22 μm | 0.62 m² |
| 71 mm | 0.45+0.22 μm | 0.62 m² | |
| 71 mm | 1.0+0.45 μm | 0.62 m² | |
| NY6TC | 71 mm | 0.22 μm | 0.84 m² |
| 69 mm | 0.45 μm | 0.68 m² |
Integrity Test Standards @10inch，20°C (DN66TC)
| Membrane Pore Size | Bubble Point | Diffusion Flow (Air) |
| 0.22+0.22 μm | ≥ 0.30 MPa (water), Air test | / |
| 0.45+0.22 μm | ≥ 0.30 MPa (water), Air test | / |
| 1.0+0.45 μm | ≥ 0.14 MPa (water), Air test | / |
Integrity Test Standards @10inch，20°C (NY6TC)
| Membrane Pore Size | Bubble Point | Diffusion Flow (Air) |
| outer diameter 71 mm-0.22 μm | ≥ 0.32 MPa, Wetted with water, Air test | / |
| 0.45 μm | ≥ 0.14 MPa, Wetted with water, Air test | / |
Bacterial Retention
| Model | Content |
| DN66TC 0.22+0.22 μm | Bacterial quantitative retention of 10⁷ cfu/cm² Brevundimonas diminuta (ATCC 19146) accordingto ASTM F838 methodology. |
| DN66TC 0.45+0.22 μm | |
| 71NY6TC 0.22 μm | Bacterial quantitative retention of 10⁷ cfu/cm² Brevundimonas diminuta (ATCC 19146) accordingto ASTM F838 methodology. |
| 71NY6TC 0.45 μm | Bacterial quantitative retention of 10⁷ cfu/cm² Serratia marcescens (ATCC14756) according to ASTM F838 methodology. |
Sterilization
| In-line steam sterilization | Up to 50 cycles (121 °C for 30 minutes and differential pressure <30KPa per cycle ) |
Regulatory Compliance
- Autoclaved filter effluent meets the USP<788> requirement of particulate matter in large volume injection.
- Component materials meet the criteria for a “Non-fiber-releasing filter” as defined in 21 CFR 210.3(b)(6).
- Aqueous extraction from a cartridge contains less than 0.25EU/ml as determined by Limulus Amebocyte Lysate (LAL), meeting requirements of USP<85>.
- Meet the requirement of USP <87> In Vitro Cytotoxicity Test.
- Component materials meet the requirements of the current USP<88> for plastic class VI-121°C.
- All component materials meet the FDA Indirect Food Additive requirements cited in 21 CFR 177-182.
- Based on the current information from our suppliers, all component materials used in the manufacture of this product are animal-free.
End Cap
Ordering Information
DN66TC (Double -layer)
| Outer Diameter | Type | Membrane Pore Size | End Cap | Nominal Length | Seal Material | Industry |
| 69mm | DN66TC | 2222 0.22+0.22 µm | DOE Double Open End | 05 5 inch | S Silicone | P |
| 71 71mm | 4522 0.45+0.22 µm | HTF 222/Fin (PBT insert) | 10 10 inch | E EPDM | ||
| 1045 1.0+0.45 µm | HSF 226/Fin (PBT insert) | 20 20 inch | V Viton | |||
| HTCG 222/Flat (PBT insert) | 30 30 inch | P FEP/PFA encapsulated O-rings | ||||
| HSCG 226/Flat (PBT insert) | 40 40 inch |
NY6TC (Single-layer)
| Outer Diameter | Type | Membrane Pore Size | End Cap | Nominal Length | Seal Material | Industry |
| 69mm | NY6TC | 0010 0.1 µm | DOE Double Open End | 05 5 inch | S Silicone | P |
| 71 71mm | 0022 0.22 μm | HTF 222/Fin (PBT insert) | 10 10 inch | E EPDM | ||
| 0045 0.45 μm | HSF 226/Fin (PBT insert) | 20 20 inch | V Viton | |||
| 0065 0.65 μm | HTCG 222/Flat (PBT insert) | 30 30 inch | P FEP/PFA encapsulated O-rings | |||
| 0080 0.8 μm | HSCG 226/Flat (PBT insert) | 40 40 inch | ||||
| 0100 1.0 μm | ||||||
| 0300 3.0 μm | ||||||
| 0500 5.0 μm |
* Example：DN66TC2222DOE05SP (DN66TC，0.22+0.22µm，Double open end，5 inch，Silicone，Pharmaceutical)
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